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PhysChem FORUM 13

Organised by: the PhysChem Forum Committee and Astex Pharmaceuticals.

Introduction

The PhysChem Forum Committee is pleased to announce our thirteenth Physical Chemistry Forum, which will be hosted by Astex Pharmaceuticals, at Cambridge, UK, on Thursday 14th March 2013.

This symposium will have the following themes: transporters as they relate to both absorption and metabolism, and using fragment-based approaches in PhysChem.

Lectures and Posters

The programme will comprise a mixture of presentations and posters with ample opportunity for questions.

The speakers include: Manfred Kansy (Roche), keynote; Patrick Barton (AstraZeneca); Brian Ethell (Novartis); Lora Mak and David Marcus (Unilever Centre for Molecular Informatics, University of Cambridge); Par Matsson (Uppsala University); Sibylle Neuhoff (Simcyp); Marcel Verdonk (Astex Pharmaceuticals); Glyn Williams (Astex Pharmaceuticals).

All posters are welcome but the presentations are reserved for non-commercial work. A prize, kindly sponsored by Astex, will be awarded to the best poster as decided by the committee.


Symposium Welcome Dinner and Keynote Talk

We shall be holding a keynote presentation by Manfred Kansy at Astex, Cambridge, followed by a "Welcome Dinner" at the Holiday Inn, Impington, Cambridge, on 13th March 2013 (the evening before the symposium).

There are no further hotel rooms available for booking through the conference, any delegates requiring accomodation at this stage will have to organise it separately.

Dinner only is 20, otherwise registration is free of charge.

There will be a free shuttle service provided from the hotel on the afternoon of the first day to the Astex site for the keynote lecture, and back again in the evening for dinner. This service will also be provided on the morning of the conference, from the hotel to Astex.


Registration

Registration is now open. Please register by completing the registration form and returning it by e-mail to: registration@physchem.org.uk, with "PCF13" as the subject. Only registered delegates will be able to attend.


Symposium Program

Keynote talk, Wednesday 13thMarch 2013

At Astex Pharmaceuticals, Cambridge

17.00 – 19.00

Registration, welcome drink

19.00 – 19.05

Welcome:

David Rees (SVP of Discovery, Astex Pharmaceuticals)

19.05 – 19.45

Keynote Lecture:

Compound Optimisation in Drug Discovery: Structure/Property ADMET Relationships

Manfred Kansy (Roche)

20.15 -

Symposium Dinner, at the Holiday Inn, Impington, Cambridge


Symposium Program, Thursday 14th March 2013

At Astex Pharmaceuticals, Cambridge

8.30 – 9.00

Late registration, if places allow

Morning session

9.20 – 9.30

Welcome

Harren Jhoti (President of Astex Pharmaceuticals

Morning session 1 - Chair: Nicola Wisher (Astex Pharmaceuticals)

9.20 – 10.00

Practical considerations for drug transporters in drug discovery

Brain Ethell (Novartis)

10.00 – 10.40

Exploring the human drug transporter interactome

Par Matsson (Uppsala University)

Tea and Posters

Morning session 2 - Chair: Toni Llinas (AstraZeneca)

11.00 – 11.40

Development, Characterisation and Application of OATP1B1 Transporter Inhibition - Property prediction

Patrick Barton (AstraZeneca)

11.40 – 12.20

The ABC of Transporters IVIVE general overview on how to scale intestinal, hepatic and/or renal transporters to PK in vivo, what we need, what we have and what we can and cannot do

Sibylle Neuhoff (Simcyp)

Lunch and Posters

Afternoon session 1 - Chair: Jonathan Burley (University of Nottingham)

13.40 – 14.20

Practical Concepts in Fragment-Based Drug Discovery

Marcel Verdonk (Astex Pharmaceuticals)

14.20 - 15.00

Mapping The Thermodynamic Landscape of Fragment-Based Drug Discovery

Glyn Williams (Astex Pharmaceuticals)

15.00 – 15.40

Tea and Posters, followed by poster prize award

Afternoon session 2 - Chair: Elisabetta Chiaparin (Astex Pharmaceuticals)

15.40 – 16.00

Molecular Transporters - Data Mining and Modelling

Lora Mak and David Marcus (Unilever Centre for Molecular Informatics, University of Cambridge)

16.00 – 16.10

Concluding remarks

Elisabetta Chiaparin and Jonathan Burley

The organisers reserve the right to make changes on the preliminary program.


Travel to the Symposium

Astex are located in the Cambridge Science Park. Click here for a map. Travel details for the Holiday Inn at Impington can be found here. Cambridge is served by direct trains from London, and has a direct rail link with Stansted and Birmingham Airports.


Acknowledgements

The committee are extremely grateful to Astex Pharmaceuticals for the kind sponsorship and hosting of this event.