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PhysChem FORUM 12

Organized by:

PhysChem Forum Committee and Medicinal Chemistry and Pharmaceutical Technology Subcommittee of the Hungarian Academy of Sciences


The PhysChem Forum Committee are pleased to announce our twelfth Physical Chemistry Forum will be held at the Hungarian Academy of Sciences (HAS), Main building, Budapest, Hungary on Thursday 19th April 2012.

This symposium will have the themes: design of lead molecules with more appropriate physico-chemical properties; models of gastro-intestinal absorption; special issues of solubility and dissolution measurements and new applications of PAMPA method.

Lectures and Posters

The programme will comprise a mixture of presentations and posters with ample opportunity dedicated to questions.

The speakers will be include: Paul Leeson (GSK), keynote; György Keserű (Gedeon Richter); Nathalie Gobeau (Novartis); Andy Davis (AstraZeneca); Edmund Kostewicz (Geothe University); Joerg Berghausen (Novartis); György Balogh (Gedeon Richter); Bálint Sinkó (Semmelweis University)

All posters are welcome but the presentations are reserved for non-commercial work. A prize, kindly sponsored by Sirius Analytical will be awarded to the best poster as dedicated by the committee.

Symposium Welcome Dinner and Keynote Talk

We shall be holding a "Welcome Dinner", including a keynote presentation by Paul Leeson at Hotel President Budapest, on 18th April 2012 (the evening before the symposium).

Fifty rooms have been reserved at the hotel for delegates. If, you would like a room please advise us using the registration form and a booking will be made on your behalf – on a first come first served bases.

Please note the cost of the pre-symposium dinner is € 40 (VAT and drinks included) and this will need to be paid upon arrival along with the delegate room rate of € 99 (single room) or € 109 (double room), which includes buffet-breakfast and all relevant taxes.

If you would like to attend the dinner and the keynote talk without staying at the hotel, payment for dinner would be required at registration at the hotel on 18th April.


There is no registration fee for this meeting, registration is now CLOSED.

Symposium Program

Welcome Dinner, Wednesday 18th April 2012

At the Hotel President, Budapest

18.00 – 19.00

Registration, Welcome drink

19.00 – 19.45

Keynote Lecture:

Impact of physicochemical properties on drug design

Paul Leeson (GSK)

20.15 -

Symposium Dinner

Symposium Program, Thursday 19th April 2012

At the building of Hungarian Academy of Sciences, Main Lecture Hall

8.30 – 9.00

Late Registration

Morning session

9.00 – 9.20


Krisztina Takács-Novák (chair of local Organising Committee)

István Greiner (president of Medicinal Chemistry Subcommittee of HAS)

Antonio Llinŕs (member of PhysChem Forum Committee)

Chair: Antonio Llinŕs (Astra Zeneca)

9.20 – 10.00

Medicinal chemistry optimizations – the case for Nature and Nurture

György Keserű (Gedeon Richter)

10.00 – 10.40

Building hypotheses using PBPK modeling

Nathalie Gobeau (Novartis)

Coffee and Posters

Chair: Karl Box (Sirius Analyticals)

11.00 – 11.40

Impact of gastro-intestinal precipitation on oral drug absorption

Edmund Kostewicz (Geothe University, Frankfurt)

Lunch and Posters

Afternoon session – Chair: Klara Valko (GSK)

13.40 – 14.20

Physico-chemical properties – the chemist’s contribution to formulation development

Joerg Berghausen (Novartis)

14.20 - 15.00

The key to controlling Compound quality through QSARs

Andy Davis (AstraZeneca)

15.00 – 15.10

Best Poster Prize

Coffee and Posters

Chair: István Greiner (Gedeon Richter)

15.40 – 16.00

Skin-PAMPA, a new method for fast prediction of skin permeability

Bálint Sinkó (Semmelweis University)

16.00 – 16.20

Grad-PAMPA based in vitro assay for drug-induced phospholipidosis in early stage of drug discovery

György Balogh (Gedeon Richter)

16.20 – 16.30

Closing the symposium


The organizers keep the right to make changes on the preliminary program.

Travel to the Symposium

Participants can reach the main building of HAS walking (8-10 min). Organisers will be waiting at the hotel hall and will guide the participants to the Academy. Click here to see a map of the route.

Hotel President, Budapest (H-1054 Budapest, Hold str. 3-5. Tel: +36-1-472-0480)

Directions to the hotel can be found at: http://www.hotelpresident.hu

Pre-symposium workshop

A pre-symposium workshop titled: “logP and pKa property prediction and training by ChemAxon technology” organized by ChemAxon Ltd. on 18th April, 16.30-17.30 at Hotel President Budapest. For more information and registration please contact: http://www.chemaxon.com/events/chemaxon-workshop-on-physchem-forum/

Post-symposium tour

For delegates who will stay an extra day in Budapest a one-day post-symposium tour is organized on Friday, 20th April by Yourways Ltd. It will commence at 8.30 am at the Hotel and will end at 18.00 (at the latest) back at the Hotel. Click here to see details.


Chemical Works of Gedeon Richter

EGIS Pharmaceuticals


Sirius Analyticals

Heath Scientific