for Physical Chemists by Physical Chemists

18th Symposium
17th Symposium 16th Symposium 15th Symposium 14th Symposium 13th Symposium 12th Symposium

PhysChem FORUM 18


The 18th PhysChem forum is announced. The meeting, "Medicines of tomorrow: new therapeutic modalities" will be hosted by Sanofi at their Frankfurt site in Germany on 23rd and 24th May 2019. The discussions will centre around new opportunities in the treatment of diseases with especially challenging drug-gable biological targets, using non-classical molecules outside the usual "rule of five" chemical space. The meeting will start around 6pm on the 23rd and conclude around 5pm on the 24th. The plenary lecture will be delivered by Dr Leonardo De Maria (AstraZeneca, Gothenburg) and will be followed by dinner at the Lindner Congress Hotel. PhysChem Forum's meetings are free to attend and delegates are not charged for registration, however delegates will have to pay their own expenses including dinner at the plenary lecture (if they wish to attend), travel, and accommodation.

Meeting sponsors

Thanks to our sponsors for their support:


All posters are welcome, A1 portrait is the appropriate size. A prize will be awarded to the best poster as decided by the committee.


Registration is now closed.


Delegates are responsible for arranging their own accommodation. We have negotiated preferential room rates for those wishing to book accommodation at the designated conference hotel, the Lindner Congress Hotel, Bolongarostr. 100, 65929, Frankfurt am Main, Germany. We have a reservation for 40 rooms for a rate of €115. The reserved rooms can be booked using the keyword PCF 2019 and are held until 24th April 2019. Booking of these special-rate rooms is not availble through the hotel web-site, but can be booked directly by phone (+49 69 330 029 11) or e-mail to the hotel ( Alternative hotels include the Dorint Main Taunus Zentrum Frankfurt/Sulzbach and the Mecure Hotel and Residenz.

Travel to the Symposium

Frankfurt has an international airport and a good train station. The address for the Sanofi site is Industriepark Höchst, Bldg. H831, 65926 Frankfurt am Main, Germany google map link and official site map.

A bus will take us from the hotel to the conference venue on Friday morning, and will also be available for an airport run after the conference ends.

Thursday 23th May 2019

At the Hotel Lindner, Frankfurt


Toni Llinas (AstraZeneca)

18.00 - 18.30

Drinks reception and late registration

18.30 - 19.30

Scaffold selection for protein-protein interaction inhibition: are there any general principles?
Leonardo De Maria (AstraZeneca, Gothenburg)

19.30 - 22.00

Symposium dinner

Friday 24th May 2019

At the Sanofi site - Industriepark Höchst, Bldg. H831, 65926 Frankfurt am Main, Germany. Google map link and official site map.


Toni Llinas (AstraZeneca)

8.30 - 9.00

Late registration and poster set-up

9.00 - 9.10


9.10 - 9.50

Experimental and computational physchem descriptors in the bRo5 chemical space
Prof Giulia Caron (University of Turin, Italy)

9.50 - 10.30

Permeability screening: 100,000 compounds later
Bernard Faller (Novartis)

10.30 - 11.00

Coffee break and poster viewing


Stephane Rodde (Novartis)

11.00 - 11.40

Oral delivery of Peptides: Mechanism of absorption of a derivatized glucagon-like peptide-1 receptor agonist
Stephen Buckley (NovoNordisk)

11.40 - 12.20

Intra-cellular uptake and trafficking of new drug modalities modulating levels of therapeutic protein targets
Elisabetta Chiarparin (AstraZeneca)

12.20 - 12.40

Flash poster session (poster authors introduce their posters, no more than 2 minutes each)

12.40 - 13.40

Lunch and poster viewing


Martin Will (Sanofi)

13.40 - 14.20

Optimisation of physico-chemical properties towards specific formulation requirements
Andreas Evers (Sanofi)

14.20 - 15.00

Cytosolic delivery of Biotherapeautics
Prof Stefaan De Smedt (Ghent University)

15.00 - 15.30

Poster prize award, coffee, poster viewing


Jonathan Burley (University of Nottingham)

15.30 - 16.10

PROTAC permeability - challenges around in-vitro measurement and IVIV disconnect
Linette Ruston (AstraZeneca)

16.10 - 16.50

Using transfer and multi-task learning to predict physico-chemical properties for peptides
Igor Tetko (German Research Center for environmental health. Munchen, Germany)

16.50 - 17.00

Wrap-up and depart

Contact Information

For more information, please send an email to

Send mail to with questions or comments about this web site.
Last modified: 21st February 2019