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Pharmaceutical cocrystals: synthesis and screening through mechanochemistryTomislav Friščić, Pfizer Institute for Pharmaceutical Materials Science and Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB21EWCocrystallisation has been recognised as a versatile method for generating improved solid forms of pharmaceutical compounds[1]. Whereas general guidelines for cocrystal (i.e. multi-component crystal) design are readily established by considering molecular recognition properties of a particular molecule, the synthesis of cocrystals still presents numerous practical challenges. This contribution will provide an overview of supramolecular synthon-based approaches to cocrystal design and demonstrate how problems of cocrystal synthesis in solution, such as solubility and solvent competition, can readily be avoided through mechanochemical approaches. Particular attention will be given to neat and liquid-assisted grinding as methods for synthesis and screening of pharmaceutical and non-pharmaceutical cocrystals[2]. T. Friščić and W. Jones Faraday Discussions 2007, 136, 171. |
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